My Brother is an inner city story of two impoverished boys, Isaiah and James. James is developmentally disabled. Their mother, L'Tisha, finds herself in a tragic situation. Dying of tuberculosis, she desperately tries to get her two boys adopted together. Finding that only Isaiah can be adopted, L'Tisha makes the only choice she feels she can make; creating an unbreakable bond of love between the boys, and hoping that bond will get them through life.