Adrien Brody and Sarah Polley star as two superstar genetic engineers who specialize in combining DNA from different animals to create incredible new hybrids. Now they want to use human DNA to revolutionize science and medicine in an amazing human-animal Splice. But when the pharmaceutical company funding their research forbids it, Clive and Elsa conduct their own experiments. The result is Dren, an amazing, strangely beautiful creature who exhibits uncommon intelligence and an array of unexpected physical developments. Dren exceeds their wildest dreams as she grows and learns at an accelerated rate ... and threatens to become their worst nightmare.