It starts with the murder of one man who was unlucky enough to discover the truth. It could end with the death of an entire city... For years the US government has been involved in a secret operation involving contrails, the white lines of condensed water vapor that jets leave in the sky. The contrails have been laced with a toxic substance deliberately sprayed on an unsuspecting populace in order to "weed out the old and the sick." Tess Rogers (Anne Heche) is a medic who prefers to work in "the field," but she's called to a hospital in Seattle when an old friend is confronted by a series of patients suffering from conditions he's never seen before. Tess wants tests to be run on the sufferers but believes they'll be dead before the results are in. Worse still, the mystery affliction mushrooms into an epidemic. With over 70 percent of Seattle dying from the virus, Tess and her son's only chance of survival is to get out of the city and find a cure.